Abstract #1862
Functional and anatomical changes of somatosensory cortex in rats recovering from severe neonatal hypoxic-ischemic encephalopathy (HIE) brain injury
Jae-Hun Kim 1 , Geun Ho Im 2 , Won Beom Jung 2 , Moon-Sun Jang 2 , Kyoung-Nam Kim 2 , Julius Juhyun Chung 3 , Sun Young Chae 3 , and Jung Hee Lee 1
1
Radiology, Samsung Medical Center, Seoul,
Seoul, Korea,
2
Center
for Molecular and Cellular Imaging, Samsung Biomedical
Research Institute, Samsung Medical Center, Seoul,
Seoul, Korea,
3
Samsung
Advanced Institute for Health Sciences & Technology,
Sungkyunkwan University, Seoul, Seoul, Korea
We examined the functional and anatomical changes of
somatosensry cortex in rats recoverying from severe
neonatal hypoxic-ischemic encephalopathy (HIE) brain
injury. In BOLD fMRI, the left brain activation was
revelaed for the left forepaw stimuatlion in HIE rats
with an evidence of functional and anatomical
disconnection between left and right hemisphere using
resting state fMRI and DTI. But more fiber tracks were
observed in frotnal brain in the HIE rats than
sham-operated rats. In this study, therefore, we found
the inter- and intra-hemispheric brain reorganization to
compensate for impaired somatosensory fuctnion in HIE
rast at 9 weeks after inducing hypoxic-ischemic brain
injury.
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