Abstract #1856
Serial and 2 TE-Acquisition 23 Na MRI for Assessment of Therapy Response in Pediatric Glioma
Vincent Kyu Lee 1 , Yongxian Qian 1,2 , Fernando Boada 3 , James Mountz 1 , and Ashok Panigrahy 1
1
Radiology, University of Pittsburgh,
Pittsburgh, Pa, United States,
2
Bioengineering,
University of Pittsburgh, Pa, United States,
3
Radiology,
New York University, NY, United States
In this study, we used serial single quantum
23
Na
imaging at two separate echo times to study pediatric
astrocytomas (total n=8 patients) to help distinguish
between proliferation and therapy response. The protein
bound sodium, predominantly associated with
intracellular sodium, was obtained by subtraction of
free sodium (long echo) from total sodium (ultrashort
echo). Using this serial 2 TE-Acquisition technique, we
were able to characterize the differences in relative
sodium concentration between tumors progressing and
those lesions responding to therapy. This methodology
may prove valuable in assessment of molecularly
targetedbased innovative treatment for differentiating
pseudoprogression or heterogeneous treatment response.
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