Abstract #1776
Regional cerebral blood volume (rCBV) bias voxel-based morphometry (VBM) in an animal study
Dirk Ernst Cleppien 1 , Lei Zheng 2 , Claudia Falfan-Melgoza 1 , Barbara Vollmayr 3,4 , Wolfgang Weber-Fahr 1 , and Alexander Sartorius 3
1
RG Translational Imaging, Department of
NeuroImaging, Central Institute of Mental Health,
Medical Faculty Mannheim, University of Heidelberg,
Mannheim, Germany,
2
Experimental Radiation
Oncology, Medical Faculty Mannheim, University of
Heidelberg, Mannheim, Germany,
3
Department
of Psychatry and Pschotherapy, Central Institute of
Mental Health, Medical Faculty Mannheim, University of
Heidelberg, Mannheim, Germany,
4
RG
Animal Models in Psychiatry, Central Institute of Mental
Health, Medical Faculty Mannheim, University of
Heidelberg, Mannheim, Germany
Neuroplastic effects of the brain are able to be
visualized by magnetic resonance imaging techniques like
voxel-based morphometry (VBM). One possible drawback
could be sensitivity to reversible changes of the brain
structure like regional cerebral blood volume (rCBV)
changes without any underlying effect on neuroplasticity.
Therefore, our hypothesis was that rCBV partially
explains the variance of VBM changes. For this, we
compared the VBM results analysed in two different ways,
one with rCBV as a covariate per voxel and one without,
in order to state the influence of rCBV on GM
probability maps.
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