Abstract #1757
Altered structural connectivity in preterm children: Network-based statistical analysis
Deanne K Thompson 1,2 , Jian Chen 1 , Christopher Adamson 1 , Richard Beare 1 , Zohra M Ahmadzai 1 , Terrie E Inder 3 , Lex W Doyle 4 , Marc Seal 1 , and Peter J Anderson 1
1
Murdoch Childrens Research Institute,
Melbourne, Victoria, Australia,
2
Florey
Institute of Neuroscience and Mental Health, Melbourne,
Victoria, Australia,
3
Brigham
and Women's Hospital, Boston, Massachusettes, United
States,
4
Royal
Women's Hospital, Melbourne, Victoria, Australia
The impact of prematurity on structural connectivity is
not yet understood. The aims of this study were to
compare network measures of structural connectivity
between very preterm (VP) and full-term children, and to
determine if network measures were correlated with
gestational age in the VP group. Results indicated that
the brains of VP children had altered network topography
compared with full-term controls. Our findings suggest
that the VP brain has a less integrated and more
segregated brain than full-term 7 year olds. This may
contribute to the poor neurodevelopmental outcomes that
are common in very VP children compared with controls.
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