Abstract #1743
What new do we learn with Myelin Water Fraction in infant white matter bundles in comparison with other MRI parameters?
Sofya Kulikova 1 , Lucie Hertz-Pannier 1 , Ghislaine Deahene-Lambertz 2 , Cyril Poupon 3 , and Jessica Dubois 2
1
UMR 663 Neurospin/UNIACT, INSERM-CEA,
Gif-sur-Yvette, France,
2
UMR
992 Neurospin/UNICOG, INSERM-CEA, Gif-sur-Yvette,
France,
3
Neurospin/UNIRS,
CEA-Saclay, Gif-sur-Yvette, France
Conventional MRI/DTI parameters provide only indirect
measures of the myelin content. Here we described the
maturation of the white matter bundles in infants (3 -
21 weeks) using Myelin Water Fraction (a more direct
myelin measure), and compared it with other parameters
(quantitative qT1 and qT2 times, fractional anisotropy
FA, mean
,
longitudinal λ║ and perpendicular λ┴ diffusivities). All
parameters demonstrated asynchronous changes with age
across different bundles. However, MWF was the most
accurate in describing maturation asynchrony as it
revealed more maturational relationships between the
bundles and didnt violate the a priori known
maturational relationships.
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