Abstract #1729
Image Registration Framework for Pixelwise Comparison of Ex Vivo MRI and Histology in Rat Model of Contusion Spinal Cord Injury
Andrew C.H. Yung 1 , Peggy Assinck 2 , Di Leo Wu 3 , Jie Liu 2 , Wolfram Tetzlaff 2,4 , and Piotr Kozlowski 1,2
1
UBC MRI Research Centre, University of
British Columbia, Vancouver, BC, Canada,
2
ICORD,
Vancouver, BC, Canada,
3
Physics,
University of British Columbia, Vancouver, BC, Canada,
4
Zoology,
University of British Columbia, Vancouver, BC, Canada
An image registration procedure was devised to compare
ex vivo MRI (DTI) and histology for the contusion model
of spinal cord injury in rats. The axonal stain sections
that are encompassed by one MRI slice are registered to
each other to form an "axon stain sum" image, which is
then aligned to the DTI-derived trace weighted image by
mutual-information affine registration. A target
registration error of 0.150 mm was measured across 9
test animals (5 slices per cord). The resultant linear
transformations can be used to perform pixelwise
comparison between MRI and histology without warping the
original data.
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