Abstract #1671
On the Effect of Fat Suppression via Chemically Selective Saturation (CHESS) Pulses on R 2 * Measurements in Patients with Transfusional Iron Overload
Axel Joachim Krafft 1 , Ralf B. Loeffler 1 , Xiao Bian 1,2 , Ruitian Song 1 , Beth M. McCarville 1 , Jane S. Hankins 3 , and Claudia M. Hillenbrand 1
1
Radiological Sciences, St. Jude Children's
Research Hospital, Memphis, TN, United States,
2
Rhodes
College, Memphis, TN, United States,
3
Hematology,
St. Jude Children's Research Hospital, Memphis, TN,
United States
Fat is a confounder in R2* based liver iron assessment
as fat-water modulations in multi gradient echo imaging
eventually affect the T2* evaluation. A simple solution
could be the inclusion of fat suppression (FS) via
chemically selective saturation (CHESS). However,
decreasing T2* times as observed with increasing liver
iron correspond to spectral profiles which overlap with
the CHESS frequency band. This partial saturation
potentially alters R2* leading to a biased iron
evaluation. Here, the effect of CHESS FS on R2* is
measured in 65 transfusional iron overload patients. A
phenomenological model is presented to explain and
correct the observed changes.
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