Abstract #1526
A fast method for 31 P localised MRS in vivo
Fabio Ginnari Satriani 1 , Emiliano Surrentino 1 , Alessandro Ricci 1 , and Rossella Canese 1
1
Cell Biology and Neurosciences Dept,
Istituto Superiore di Sanit, Rome, Italy
31P MRS offers a powerful approach to non-invasively
measure extracellular pH (pHe) and
intracellular/extracellular pH gradient in vivo. 31P MRS
techniques require long acquisition times.The exogenous
cell-impermeant 31P reporter 3-aminopropyl phosphonate
(3-APP) used for pHe evaluation should be retained
within the tumor for the entire duration of the
measurements. This condition is not always fulfilled in
highly vascularised tumors. We here propose a new
technique for fast 31P MRS in highly vascularised
tumours by improving the localization of the surface
coil (positioned on superficial tumours) with a
saturation band which dephases the signal arising from
the mouse body.
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