Abstract #1424
Localized Spectroscopy Without J-modulation at Ultra High Field
Clark Lemke 1 , Uzay Emir 1 , Peter Jezzard 1 , Stuart Clare 1 , and Jamie Near 2
1
FMRIB, University of Oxford, Oxford,
Oxfordshire, United Kingdom,
2
Douglas
Institute, McGill University, Verdun, Quebec, Canada
In vivo quantification of coupled metabolites is
hampered by J-modulation. J-modulation manifests as an
echo time (TE) dependent modulation on the metabolite
signal leading to increased signal loss over and beyond
other relaxation processes. Short TE spectroscopy avoids
the effects of J-modulation but is complicated by a
broad baseline extending over the relevant frequency
range. This baseline can lead to decreased accuracy of
metabolite quantification. Here we present a localized
metabolite quantification pulse sequence designed to
remove J-modulation at long TE (<40 ms) to avoid
baseline contamination. The sequence (PRESS-JR) is
presented with phantom measurements.
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