Abstract #1419
Two-voxel Hadamard encoded semi-LASER spectroscopy for in vivo MRS at ultra-high field
Adam Berrington 1 , Peter Jezzard 1 , Stuart Clare 1 , and Uzay Emir 1
1
FMRIB Centre, University of Oxford, Oxford,
Oxfordshire, United Kingdom
Large chemical shift displacement errors in MRS at
ultra-high field can limit SNR and lead to spurious
J-evolution across the VOI. Multi-voxel approaches are
particularly susceptible to poor localisation, resulting
in signal bleed between voxels. By incorporating two-voxel
Hadamard encoding with a semi-LASER localisation
sequence at 7T, we show that both CSD and inter-voxel
bleeding can be minimised. Demonstrating this method in
vivo on 4 volunteers, we are able to obtain highly
resolved spectra with efficient water suppression
simultaneously from both voxels. Metabolites such as
GABA, Glu, Lac and Ins can be reliably determined with
the method.
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