Abstract #1401
Combining MRI with PET for partial volume correction improves image-derived input functions in mice
Eleanor Evans 1 , David Izquierdo Garcia 2 , Guido Buonincontri 1 , Carmen Methner 3 , Rob C Hawkes 1 , Thomas Kreig 3 , T. Adrian Carpenter 1 , and Stephen J Sawiak 1,4
1
Wolfson Brain Imaging Centre, University of
Cambridge, Cambridge, United Kingdom,
2
Athinoula
A. Martinos Centre for Biomedical Imaging, Harvard
University, Massachusetts, United States,
3
Department
of Medicine, University of Cambridge, Cambridge, United
Kingdom,
4
Behavioural
and Clinical Neurosciences Institute, University of
Cambridge, Cambridge, United Kingdom
Kinetic modelling in Positron Emission Tomography (PET)
allows metabolic measures to be obtained, but requires
the tracer arterial input function (AIF). Blood sampling
to acquire the AIF is prohibitive in mice due to low
blood volumes. Image-derived AIFs are therefore
preferred, although their extraction from blood vessels
is hampered by low spatial resolution (~1.5-2mm). We
found that using an AIF extraction method which employed
partial volume correction (PVC) in the mouse heart was
crucial for deriving accurate AIFs and gave best results
when ROIs were based on MRI data rather than PET data.
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