Abstract #1263
Changes in Muscle Mitochondrial Energetics in Vivo and Physical Fitness in Operable Rectal Cancer Patients Following Neoadjuvant Chemoradiotherapy An Observational Pilot Study
Malcolm A West 1 , Lisa Loughney 2 , Michael PW Grocott 3 , Sandy Jack 3 , and Graham J Kemp 1
1
Magnetic Resonance and Image Analysis
Research Centre, Institute of Ageing and Chronic
Disease, University of Liverpool, Liverpool, Merseyside,
United Kingdom,
2
Critical Care Research Area,
NIHR Respiratory BRU, University Hospital Southampton,
Southampton, Hampshire, United Kingdom,
3
Integrative
Physiology and Critical Illness Group, Faculty of
Medicine, University of Southampton, Hampshire, United
Kingdom
This prospective study of 12 locally advanced rectal
cancer patients aims to investigate the effects of
standardised neoadjuvant chemoradiotherapy (NACRT) on
objectively measured mitochondrial energetics and
physical fitness using 31-phosphorus magnetic resonance
spectroscopy (31P MRS) and cardiopulmonary exercise
testing (CPET). A significant reduction in oxygen uptake
at estimated lactate threshold, oxygen uptake at Peak
exercise (ml.kg-1.min-1), and a parallel decrease in
post-exercise phosphocreatine (PCr) recovery rate
constant (kPCr min-1 suggests that mitochondrial
mechanisms are important in the loss of fitness induced
by NACRT.
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