Abstract #1231
Using 31 P-MRS to Explore the Effects of Iron Deficiency on Murine Skeletal Muscle Function and Metabolism During Exercise
M. Kate Curtis 1 , Lowri E. Cochlin 2 , Mark A. Cole 3 , David P. O'Neill 1 , Michael S. Dodd 1,4 , Damian J. Tyler 1,4 , Kieran Clarke 1 , and Peter A. Robbins 1
1
Department of Physiology, Anatomy and
Genetics, University of Oxford, Oxford, United Kingdom,
2
Department
of Physiology, Anatomy and Genetics, PulseTeq Ltd,
Oxford, United Kingdom,
3
Department
of Life Sciences, University of Nottingham Medical
School, Nottingham, United Kingdom,
4
Oxford
Centre for Clinical Magnetic Resonance Research,
Radcliffe Department of Medicine, University of Oxford,
Oxford, United Kingdom
Physical work or exercise capacity has been widely
reported as being impaired by iron deficiency in both
human and animal studies. The aim of this project was to
develop a technique that allows for the simultaneous
assessment of force production, fatigue resistance and
metabolic function of murine gastrocnemius muscle during
exercise. To address this, a method of in vivo
gastrocnemius muscle stimulation was successfully
established, which allows the simultaneous measurement
of energetics, by 31P MRS, and induced force production
in a murine model of altered iron status.
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