Abstract #1229
Post-Contractile Blood-Oxygenation Level Dependent (BOLD) Contrast in Skeletal Muscle at 7T
Theodore F Towse 1,2 , Christopher P Elder 1,3 , Emily C Bush 4,5 , Benjamin T Childs 4 , Samuel W Klockenkemper 4 , Shea A Sabin 4 , Jared T Bullock 4 , and Bruce M Damon 6,7
1
Physical Medicine and Rehabilitation,
Vanderbilt University, Nashville, TN, United States,
2
Vanderbilt
Institute of Imaging Science, Vanderbilt University,
Nashville, TN, United States,
3
Radiology
and Radiological Sciences, TN, United States,
4
Vanderbilt
University Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
5
Vanderbilt
University Biomedical Engineering, TN, United States,
6
Radiology
and Radiological Sciences, Vanderbilt University,
Nashville, TN, United States,
7
Molecular
Physiology and Biophysics, Vanderbilt University, TN,
United States
Post-isometric contraction proton density and
T2*-weighted signal transients acquired at 3T have been
used to characterize muscle microvascular function in
both the normal and pathologic states. At 7T, muscle
BOLD contrast is expected to be more influenced by
extravascular BOLD mechanisms than is observed at 3T,
where muscle BOLD contrast is dominated by intravascular
mechanisms. Our preliminary studies suggest BOLD based
functional imaging of muscle is feasible at 7T and may
afford greater insight into microvascular dysfunction by
offering greater specificity to microvascular-scale
structures and a higher contrast-to-noise ratio than are
achieved at lower field strengths.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
