Abstract #1196
Quantitative MRI of Osteoarthritis for Multicenter Trials: Standardization between Different Centers and Manufacturers
Feliks Kogan 1 , Jarrett Rosenberg 1 , Emily J McWalter 1 , Daniel Park 2 , Stephen Matzat 1 , Kevin Prekins 2 , Catherine Tran 1 , Merideth Taylor 2 , Bragi Sveinsson 1 , Rex Newbould 2 , Uche Monu 1 , Haonan Wang 2 , Neal K Bangerter 2 , and Garry E Gold 1
1
Radiology, Stanford University, Stanford,
CA, United States,
2
Electrical
& Computer Engineering, Brigham Young University, Provo,
UT, United States
In this study, we assessed the repeatability and
reproducibility of quantitative MRI measurements of
cartilage morphometry and tissue parameters intra-site
and between sites and manufacturers. Quantitative
measurements of tissue morphometry, T2, and sodium
concentration were repeatable within a given site as
determined by a high concordance correlation
coefficient. Between sites with different manufacturers,
correlation was high for morphologic imaging. Sodium
concentration measurements showed a correctable bias
while use of different acquisition sequences on
different platforms for T2 measurements showed errors
that are not easily correctable.
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