Abstract #1194
Significant Influences of Loading on T1 in Sub-tissue Zones of Canine Articular Cartilage in Experimental OA
Jihyun Lee 1 and Yang Xia 1
1
Physics and Center for Biomedical Research,
Oakland University, Rochester, Michigan, United States
This study aims to quantify the loading-modified
topographical and zonal T1 in articular cartilage in
early experimental canine OA using MRI at the 17.6m
resolution and when the tissue was soaked with the Gd
contrast agent. Both OA and mechanical compression were
found to be able to alter the T1 relaxation time of
articular cartilage at each sub-tissue zone and
topographically, which provide a better understanding of
the MRI properties of cartilage during joint loading.
This result could help to design effective protocols in
clinical MRI to better detect and manage the articular
diseases.
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