Abstract #1167
Reproducibility of In Vivo Bound and Pore Water Imaging of Cortical Bone
Mary Kate Manhard 1,2 , Robert Adam Horch 2,3 , Daniel F Gochberg 2,3 , Jeffry S Nyman 4 , and Mark D Does 1,2
1
Biomedical Engineering, Vanderbilt
University, Nashville, TN, United States,
2
Vanderbilt
University Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
3
Radiology
& Radiological Sciences, Vanderbilt University,
Nashville, TN, United States,
4
Department
of Orthopaedics & Rehab, Vanderbilt University,
Nashville, TN, United States
The previously proposed DAFP and AIR sequences were
applied to in vivo clinical scans on three human
subjects on the wrist and the lower leg. Bound and pore
water concentration maps were obtained from the images
on cortical bone of the radius and tibia. Each scan was
repeated three times and the reproducibility was
investigated as the inter-scan variability. Good
repeatability was found (≈10% standard error per ROI),
verifying these methods as diagnostic tools for
assessing bone quality.
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