Abstract #1161
Tracking tissue oxygenation status and response using Diffusion-Weighted functional MRI
Zhongwei Zhang 1 , Rami R Hallac 1 , Qing Yuan 1 , Peter Peschke 2 , and Ralph P Mason 1
1
Department of Radiology, The University of
Texas Southwestern Medical Center, Dallas, TX, United
States,
2
Clinical
Cooperation Unit Radiation Oncology, German Cancer
Research Center, Heidelberg, Germany
The diffusion-sensitized fMRI (DfMRI) has the potential
to provide noninvasive measurements of tissue
oxygenation using oxygen as an endogenous paramagnetic
contrast agent, in this study, we compared DfMRI
response with BOLD, TOLD responses to gas breathing
challenge under different baseline pO2 level. The
feasibility of DfMRI for tracking tissue oxygenation
status was evaluated. Our study showed that DfMRI is a
powerful tool to tracking tissue oxygenation status and
it can also provide the extent of response when
combining baseline pO2 measurement.
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