Abstract #1157
Longitudinal Generalized Q-Sampling MRI Evaluation in Rabbit Brain after Cerebral Hemisphere Radiation Exposure
Chao-Yu Shen 1,2 , Fang-Yu Nien 1 , Zhen-Hui Li 1 , Yeu-Sheng Tyan 1,2 , and Jun-Cheng Weng 1,2
1
School of Medical Imaging and Radiological
Sciences, Chung Shan Medical University, Taichung,
Taiwan,
2
Department
of Medical Imaging, Chung Shan Medical University
Hospital, Taichung, Taiwan
Radiation therapy is widely used for the treatment of
both primary and metastatic brain tumors and can lead to
cellular, vascular and axonal injury and further
behavioral deficits. Imaging assessment of the brain
damage caused by radiation therapy is very important for
determining patient prognoses. Previously we used
diffusion tensor imaging (DTI) and T2-weighted imaging
(T2WI) to evaluate post-irradiation brain injury. To
improve evaluation of the neuro-toxic adverse effects of
irradiation treatment in both gray and white matter
structures, in this study we longitudinally evaluated
the changes in various brain compartments on a clinical
MR scanner by using generalized q-sampling imaging (GQI)
indices mappings, generalized fractional anisotropy (GFA),
quantitative anisotropy (QA) and isotropic value (ISO)
of the orientation distribution function (ODF), for
single sub-lethal high dose (30 Gy) cerebral hemisphere
exposure radiation-induced brain injury on adult rabbit
model.
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