Abstract #1134
Feasibility of MR-guided needle-directed intratumoral HoMS delivery for localized radiation therapy in a large tumor-model
Bo Sybren van Leeuwen 1 , Sebastiaan Alexander van Nimwegen 2 , Frank Zijlstra 3 , Chris Oerlemans 3 , Jolle Kirpensteijn 2 , Johannes Franciscus Nijsen 4 , and Peter Roland Seevinck 3
1
Dept. of Clinical Sciences of Companion
Animals, Faculty of Veterinary Medicine Utrecht
University, Utrecht, Utrecht, Netherlands,
2
Dept.
of Clinical Sciences of Companion Animals, Faculty of
Veterinary Medicine Utrecht University, Utrecht,
Netherlands,
3
Image
Sciences Institute, Imaging Division, University Medical
Center Utrecht, Utrecht, Utrecht, Netherlands,
4
Imaging
Division, University Medical Center Utrecht, Utrecht,
Netherlands
In this study, we demonstrated the feasibility of MR-guided
needle-directed intratumoral 165HoMS delivery in a large
tumor model. MRI facilitated tumor visualization, entry
point determination and needle trajectory planning. The
presented approach enabled dynamic monitoring of the
needle insertion and needle tip positioning in the
tumor, allowing intraprocedural optimization of HoMS
delivery. coRASOR reconstruction was demonstrated to
improve needle visualization by generating positive
contrast, causing the titanium needles to be easily
identified with high spatial and temporal resolution
when applied prospectively. Future work should also aim
at facilitating intraprocedural dosimetry to enable
optimization of the number of injection sites and the
amount of HoMS to be delivered to eventually provide a
favorable dose distribution on the tumor, while sparing
the healthy tissue.
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