Abstract #1105
Error Quantification in Relaxivity Rate Change (∆R1) Due to Systematic Errors in Dynamic Contrast Enhanced MR Studies
Hassan Bagher-Ebadian 1,2 , Siamak P. Nejad-Davarani 3,4 , James R Ewing 2,3 , and Hamid Soltanian-Zadeh 1,5
1
Radiology, Henry Ford Hospital, Detroit, MI,
United States,
2
Physics,
Oakland University, Rochester, MI, United States,
3
Neurology,
Henry Ford Hospital, Detroit, MI, United States,
4
Biomedical
Engineering, University of Michigan, Ann Arbor, MI,
United States,
5
CIPCE,
ECE Dept., University of Tehran, Tehran, Iran
In Dynamic Contrast Enhanced (DCE) MR studies,
assessment of systematic errors propagated in
longitudinal relaxation rate change, ∆R1(t), is
important since errors in ∆R1(t) profile, biases
permeability parameters estimated in
DCE-MR-Pharmacokinetic analysis. Herein, we asses and
quantify the biasing of ∆R1(t) profile at different
enhancement-ratios in the DCE-T1
(3D-Spoiled-Gradient-Echo) experiment. Biasing arises
from the deviation of actual-to-nominal
dynamic-flip-angle and also the systematic error in
estimating of resting T1 in Variable-Flip-Angle
experiments prior to the contrast agent administration.
Results imply that ∆R1(t), regardless of its enhancement
ratio, is more susceptible to the underestimations of T1
and dynamic-flip-angel compared to their overestimations
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