Abstract #1084
The effect of choline kinase-α inhibition on lipid metabolism of breast cancer cells
Noriko Mori 1 , Flonn Wildes 1 , Kristine Glunde 1 , and Zaver M. Bhujwalla 1
1
The Russell H. Morgan Department of
Radiology and Radiological Science, The Johns Hopkins
University School of Medicine, Baltimore, Maryland,
United States
Phosphatidylcholine has important roles in membrane
structure and cell signaling. Increased levels of
choline kinase (Chk)-α and phosphocholine (PC) are
consistently observed in aggressive cancers.
Understanding the roles of Chk-α in cancer can result in
new therapies. We previously showed that the Chk-α
protein, but not PC was essential for cell survival of
two triple negative breast cancer cell lines, MDA-MB-231
and SUM149, using a Chk-α inhibitor which reduces PC but
not Chk-α protein. Here we have investigated lipid
metabolism in these breast cancer cells and identified
PtdCho as an important factor in breast cancer cell
survival.
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