Abstract #1080
Metabolic characterization of locally advanced breast cancer in response to NAC treatment
Shiva Shojaei Moghaddam 1 , Maria D. Cao 1 , Guro F. Giskedegrd 1 , Hans E. Fjsne 1 , Steinar Lundgren 1 , Per E. Lnning 2 , and Tone F. Bathen 1
1
NTNU, Trondheim, Sr-Trndelag, Norway,
2
University
of Bergen, Begren, Norway
Metabolic profiling has shown promise in breast cancer
characterization. High resolution magic angle spinning
MR spectroscopy was performed on biopsies obtained
before and after neoadjuvant chemotherapy in patients
with locally advanced breast cancer. Quantitative
metabolite concentrations were related to the treatment
response and survival of the patients.
Glycerophosphocholine, Glycine and myo-Inositol showed
significant changes in response to NAC treatment among
survivors, responders and non-responders. Findings from
this study indicate that the MR metabolic profile in
response to NAC treatment can assist the prediction of
prognosis and clinical treatment response in LABC
patients.
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