Abstract #1076
Aggressiveness Biomarker for Prostate Cancer in ADC-T2W MR Feature Space
Alpay zcan 1 , Baris Trkbey 2 , Peter Choyke 2 , and Seong K. Mun 1
1
Virginia Polytechnic Institute and State
University, Arlington, VA, United States,
2
National
Cancer Institute, Bethesda, MD, United States
Accurate localization of prostate cancer (PCa) is
fundamental for effective surveillance and, guiding
diagnostic and therapeutic interventions. However, an
imaging biomarker is absent for this goal. Herein, the
ADC-T2W MR feature space (MR-FS) is proposed for image
guided PCa strategies. An interactive in-house software
was implemented to incorporate objectively and directly
physician's experience into the discovery process. The
analysis of a 44 patient cohort revealed a specific
region in MR-FS distinguishing aggressive from indolent
PCa. By observing the pixels associated with the
aggressive region, effective biopsy and therapy target
localization and, active surveillance is achieved.
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