Abstract #1059
Metabolomic Imaging for Human Prostate Cancer Detection using MR Spectroscopy at 7-T
Romy Langhammer 1,2 , Leo L. Cheng 1 , Johannes Nowak 3 , Shulin Wu 1 , W. Scott McDougal 1 , Chin-Lee Wu 1 , and Eva M. Ratai 1
1
Massachusetts General Hospital, Harvard
Medical School, Boston, Massachusetts, United States,
2
Institute
of Radiolgy, Department for Neuroradiology, University
Hospital Wuerzburg, Wuerzburg, Bavaria, Germany,
3
Institute
of Radiology, Department for Neuroradiology, University
Hospital Wuerzburg, Wuerzburg, Bavaria, Germany
The project aims to develop a non-invasive diagnostic
test for prostate cancer. Metabolomic imaging maps of
thirty whole prostates were created and analyzed, using
magnetic resonance spectroscopy (MRS) at 7T. To test the
functionality and reliability of this system, the
outcome has been compared with the histopathology
findings. In 61% of the samples, MRS detected cancer
lesions in the same locations as were identified in the
histopathology analysis; the histological regions that
were not detected had significantly lower tumor volumes.
Furthermore, a "Malignancy Index" can significantly
differentiate between cancerous and benign MRS
suspicious regions.
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