Abstract #1031
DWI of Breast at 3T: Effects of Fibroglandular Tissue Composition and Background Parenchymal Enhancement in Patients with Malignant and Benign Lesions
Soledad Milans 1 , Sujata Patil 2 , Elizabeth Morris 2 , and Sunitha Thakur 1
1
Memorial Sloan-Kettering Cancer Center, New
York, NY, United States,
2
Memorial
Sloan-Kettering Cancer Center, NY, United States
The amount of fibroglandular tissue (FGT) density and
the level of background parenchymal enhancement (BPE)
are MRI features of normal breast. Studies showed
increased BPE to be strongly predictive of breast cancer
odds as with increased FGT. We propose to evaluate the
effect of FGT density and BPE on ADC values in patients
with malignant and benign findings at 3.0T. FGT-ADC
values were significantly higher in patients with
malignant lesions with higher density compared to lower
density (p=0.0073). In patients with benign lesions,
difference is smaller between both groups (p=0.015). No
significant difference was observed in FGT-ADC values
with BPE.
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