Abstract #1011
Mapping the Distinct Single-Vessel Vascular Contribution to BOLD and CBV fMRI
Xin Yu 1 , Stephen J. Dodd 1 , Afonso C. Silva 1 , and Alan P. Koretsky 1
1
National Institute of Neurological Disorders
and Stroke, National Institutes of Health, Bethesda, MD,
United States
Hemodynamic signal from individual venules can be
detected directly with fMRI. Here, the hemodynamic
signal from BOLD and CBV fMRI was measured at high
temporal (100ms) and spatial (150x150m) resolution in
layers 4/5 of the rat forepaw S1 with a fast
gradient-echo MRI sequence. Distinctly different voxels
were activated in BOLD vs CBV fMRI. In contrast to the
BOLD activated voxels primarily located within
penetrating venules, CBV activated voxels were primarily
located to penetrating arterioles. This result makes it
possible to directly image the CBV and BOLD response at
the level of single-vessels to better understand
neurovascular coupling.
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