Abstract #0984
Quantified pH imaging with hyperpolarized 13 C-Bicarbonate
David Johannes Scholz 1 , Martin A. Janich 2 , Annette Frank 3 , Ulrich Kllisch 1 , Jan H. Ardenkjaer-Larsen 4,5 , Rolf F. Schulte 2 , Markus Schwaiger 3 , Axel Haase 1 , and Marion I. Menzel 2
1
IMETUM, Technische Universitt Mnchen,
Munich, Germany,
2
GE
Global Research, Munich, Germany,
3
Nuclear
Medicine, Technische Universitt Mnchen, Munich,
Germany,
4
Technical
University of Denmark, Copenhagen, Denmark,
5
GE
Healthcare, Copenhagen, Denmark
Hyperpolarized
13
C-Bicarbonate
pH mapping enables the opportunity to investigate a key
parameter in many biochemical processes, the pH, which
is relevant for a broad range of disease
characterization such like cancer, inflammatory diseases
(e.g. Alzheimer disease, multiple sclerosis and
osteoarthritis), hypoxia and many others.
In
vitro
and
in
vivo
quantification
of pH, acquired spatially and time resolved helps to
reveal the potential and the limits of the method. pH
mapping was applied
in
vivo
using
tailor-made spectral-spatial pulse design and
acquisition techniques on rats, investigating induced
metabolic alkalosis in kidneys and sterile inflammation.
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