Abstract #0982
Dynamic Ultrafast 2D Exchange Spectroscopy (EXSY) of Hyperpolarized Substrates
Christine Leon Swisher 1,2 , Peder E.Z. Larson 1,2 , Bertram L. Koelsch 1,2 , Subramaniam Sukumar 1 , Renuka Sriram 1 , Justin Delos Santos 1 , Adam B. Kerr 3 , John M. Pauly 3 , John Kurhanewicz 1,2 , and Daniel B. Vigneron 1,2
1
Department of Radiology and Biomedical
Imaging, University of California, San Francisco, San
Francisco, CA, United States,
2
UC
Berkeley-UCSF Graduate Program in Bioengineering, San
Francisco, CA, United States,
3
Magnetic
Resonance Systems Research Laboratory, Department of
Electrical Engineering, Stanford University, Stanford,
CA, United States
We present for the first time a simple ultrafast method
for acquiring dynamic 2D Exchange Spectroscopy (EXSY)
using MAD-STEAM. This technique reconstructs 2D EXSY
spectra from 1D spectra based on phase accrual during
the echo time. Utilizing single-step encoding and
single-shot acquisition, it is ideal for dynamic imaging
of many exchange pathways and applicable to
hyperpolarized substrates. We have validated this method
in simulations, hyperpolarized hydration experiments,
and cell studies where forward and backward exchange of
pyruvate-lactate and pyruvate-hydrate were resolved in
real-time. This new approach could improve specificity
to cancer metabolism via isolation of directionality of
metabolic pathways.
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