Abstract #0974
Histological Relationship with High-Resolution Diffusion Kurtosis Imaging in the Cerebral Cortex
Austin Ouyang 1 , Xinzeng Wang 1 , Mihovil Pletikos 2 , Nenad Sestan 2 , and Hao Huang 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States,
2
Department
of Neurobiology, Yale University, New Haven, CT, United
States
Diffusion kurtosis imaging (DKI) provides greater
sensitivity to microstructural differences due to its
capability of quantifying non-Gaussian diffusion
properties; however, the biological interpretation of
these DKI metrics has yet to be fully characterized,
especially in the cerebral cortex. In this study, we
acquired high resolution DKI data of a macaque brain and
compared the DKI metrics with histological image of
neurofilament staining. Slices with large cortical
variations in mean kurtosis (MK) corresponded well with
the density of neurofilament staining.
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