Abstract #0963
Altered fatty acid profile of periprostatic adipose tissue in prostate cancer patients: an MR spectroscopic study
Palamadai N Venkatasubramanian 1 , George Iordanescu 1 , Kristian Novakovic 2 , Jennifer Doll 3 , Charles Brendler 2 , and Alice M Wyrwicz 1
1
Radiology, NorthShore University
HealthSystem, Evanston, IL, United States,
2
Surgery,
NorthShore University HealthSystem, Evanston, IL, United
States,
3
Biomedical
Sciences, University of Wisconsin at Milwaukee,
Milwaukee, WI, United States
Using ex vivo MR spectroscopy we detected alterations in
the fatty acid composition of periprostatic adipose
tissue from obese prostate cancer patients, relative to
their subcutaneous adipose tissue. The altered
periprostatic adipose composition was found to have
predictive potential for a pathological criterion for
aggressive prostate cancer, namely, extracapsular
extension. Our results suggest that in vivo MR
spectroscopy may have potential for developing a
noninvasive biomarker for aggressive prostate cancer.
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