Abstract #0957
Multimodal imaging analysis in the assessment of gray and white matter damage in multiple sclerosis
Niels Bergsland 1,2 , Marcella Lagan 1 , Eleonora Tavazzi 1 , Matteo Caffini 2 , Paola Tortorella 1 , Marco Rovaris 1 , and Giuseppe Baselli 2
1
Istituto IRCCS Santa Maria Nascente,
Fondazione Don Gnocchi, Milan, Italy,
2
Dipartimento
di Elettronica, Informatica e Bioingegneria, Politecnico
di Milano, Milan, Italy
The study of the relationship between grey matter (GM)
and white matter damage in multiple sclerosis (MS) is
relevant. This was a cross-sectional MRI study of 30 MS
patients. Probabilistic tractography data and lesion
load of the cortico-spinal tract (CST) were obtained.
Measures of motor cortex (MC) thickness and area were
obtained with Freesurfer. MC thickness correlated with
CST mean diffusivity and lesion volume, and EDSS. MC
surface area correlated with EDSS. Our findings further
characterize the GM damage and confirm its impact of on
disability. CST damage correlated with cortical
thickness supporting the link between GM and WM damage.
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