Abstract #0902
Preferably large fiber damage in the corpus callosum of progressive MS compared with relapsing MS and controls
Bailey Komishke 1 , Luanne Metz 2 , Lenora Brown 2 , and Yunyan Zhang 2
1
University of British Columbia, Vancouver,
BC, Canada,
2
University
of Calgary, AB, Canada
We recruited 19 patients with advance SPMS and mild RRMS
and 19 controls to determine whether tissue damage
differs across different regions of the corpus callosum
(CC) and between cohorts. Using whole-brain sagittal
DTI, we developed a simple template to partition the CC
into 6 segments. We found tissue organization different
between CC segments and tissue damage the greatest in
the body and splenium, which are comprised of
large-caliber axons, of SPMS. There was only minimal
tissue injury in RRMS but in similar locations. Our
results suggest the vulnerability of large-caliber axons
likely causing advanced disability in SPMS.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
