Abstract #0877
Robust Cardiac BOLD MRI using an fMRI-like approach with Repeated Stress Paradigms
Aurelien F. Stalder 1 , Michaela Schmidt 1 , Andreas Greiser 1 , Peter Speier 1 , Jens Guehring 1 , Matthias G Friedrich 2,3 , and Edgar Mueller 1
1
Siemens AG Healthcare Sector, Erlangen,
Germany,
2
Departments
of Cardiology and Radiology, Montreal Heart Institute,
Universit de Montral, Montreal, QC, Canada,
3
Departments
of Cardiac Sciences and Radiology, University of
Calgary, Calgary, AB, Canada
The diagnostic accuracy of cardiac BOLD MRI remains
limited by its signal amplitude being in the order of
magnitude of noise and signal variations due to hardware
instabilities or other physiological effects, and
cardiac and respiratory motion. In this work, we
combined a fast BOLD-sensitive acquisition technique
with elastic motion-correction and an fMRI-like (GLM)
data analysis. The method was applied in 13 volunteers
performing repeated breath-holds. Pixel and ROI based
analysis derived statistically significant BOLD
activations in the myocardium. Robust
oxygenation-sensitive CMR as a non-invasive
contrast-free technique may become an alternative to
current diagnostic tools in patients with suspected CAD.
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