Abstract #0851
Metabolite profiling and metabonomic approaches of fecal extracts from patients with chronic ulcerative colitis and colorectal cancer based on 9.4T NMR spectroscopy and pattern recognition
Yan Lin 1 , ChengKang Liu 1 , Zhiwei Shen 1 , and Renhua Wu 1
1
Radiology Department, Second Affiliated
Hospital, Shantou University Medical College, Shantou
City, Guangdong Province, China
This present study is a NMR-based metabolomics
approaches coupled with pattern recognition methods to
evaluate the ability to characterize the metabolic
fingerprint of fecal extracts from patients with
ulcerative colitis (UC) and colorectal cancer (CRC). The
most significant metabolites for classification include
short-chain fatty acids, alanine, isoleucine, leucine,
valine, glutamate, glycerol and the spectra in the
aromatic region (6.6C8.2ppm), suggesting changes in the
gut microbial community or malabsorption. This work
shows the potential of MR-based metabolomics of fecal
extracts in providing useful non-invasive diagnostic
information for UC and CRC diseases and may further our
understanding of colonic cancer mechanisms.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
