Abstract #0753
Normalizing cerebrovascular reactivity map via concomitant CO2 and O2 challenge
Peiying Liu 1 , Yang Li 1 , and Hanzhang Lu 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States
Cerebrovascular reactivity (CVR), measured by combining
BOLD MRI and hypercapnia, is an important marker of
cerebrovascular function. An undesirable feature of
current CVR mapping results is that the image shows very
strong contrast in large drains due to large blood
volume in these voxels, which reduces the conspicuity of
true CVR abnormalities. The present work demonstrates
that normalizing CO2-CVR by O2-reactivity can
effectively reduce the influence of cerebral blood
volume on the results. Furthermore, a novel breathing
paradigm with concomitant CO2/O2 challenge is developed
to obtain CO2 and O2 reactivity maps in a single scan
without increasing the study duration.
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