Abstract #0702
Spatiotemporal Encoding Diffusion Weighted Imaging of the Breast: Comparison with SE-EPI-based methodology
Eddy Solomon 1 , Noam Nissan 1,2 , Amir Seginer 1 , Edna Furman-Haran 3 , Myra Shapiro-Feinberg 4 , Hadassa Degani 2 , and Lucio Frydman 1
1
Chemical Physics, Weizmann Institute of
Science, Rehovot, Israel,
2
Biological
Regulation, Weizmann Institute of Science, Rehovot,
Israel,
3
Biological
Services, Weizmann Institute of Science, Rehovot,
Israel,
4
Radiology,
Meir Hospital, Kfar Saba, Israel
A recently proposed MRI methodology, SPatio-temporal
ENcoding (SPEN), was employed to quantify apparent
diffusion coefficients in breast. SPEN is highly robust
in terms of overcoming B0-inhomogeneities and
heterogeneous chemical shift environments, and hence
could present advantages in these challenging studies.
Diffusion SPEN measurements were carried out at 3T and
included healthy female volunteers and patients with
biopsy-confirmed breast cancer. Substantial advantages
in terms of both anatomical image qualities and
diffusional information vis--vis EPI were observed,
confirming SPENs ability to yield reliable ADC values
and reveal a reduction of ADC in cancerous tissues.
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