Abstract #0700
Macromolecule Suppressed GABA Editing using Spectral Spatial RF Pulses
Meng Gu 1 , Adam B. Kerr 2 , Ralf E. Hurd 3 , and Daniel M. Spielman 1
1
Radiology, Stanford University, Stanford,
California, United States,
2
Electrical
Engineering, Stanford University, Stanford, California,
United States,
3
GE
Healthcare, Menlo Park, California, United States
MEGA PRESS has been used to edit the GABA resonance at
3ppm. Due to the wide transition bandwidth of the
editing pulse, macromolecule resonances are coedited. To
suppress macromolecule signals, a symmetric suppression
method has been proposed resulting in reduced GABA
signal. We present a new editing method by incorporating
spatial and spectral selectivity into the PRESS
refocusing RF pulses to achieve both GABA editing and
macromolecule suppression. Phantom studies showed higher
edited GABA signal compared with MEGA PRESS and 90%
macromolecule suppression. In-vivo studies demonstrated
significantly higher edited GABA signal compared with
MEGA PRESS.
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