Abstract #0690
Modulating Activity in the Olfactory Bulb Leads to Reversible Changes in Size and Alter Migration of New Neurons
Nikorn Pothayee 1 , Diana Cummings 2 , Leonardo Belluscio 2 , and Alan Koretsky 1
1
Laboratory of Functional and Molecular
Imaging, NINDS, NIH, Bethesda, MD, United States,
2
Developmental
Neural Plasticity Section, NINDS, NIH, Bethesda, MD,
United States
In mammalian, the migrating new neuron precursors play
an important role in maintaining neuronal homeostasis in
olfactory bulbs (OB). Various techniques based on
optical and electron microscopy have been used to study
cell migration and neuronal turnover in OB. However,
none of these techniques enable longitudinal study of
the whole brain within the living subject. We utilized
in situ MRI labeling in combination with MRI volumetry
to address the question of whether change in olfactory
sensory level alter migrating speed and pattern of NPC
integration in OB as well as changes in OB sizes in
response to alteration of activity deprivation and
recovery.
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