Abstract #0686
Hot-spot 19F imaging of stem cell transplantation into the intrathecal space in a large animal model
Miroslaw Janowski 1,2 , Guan Wang 1 , Jiadi Xu 3 , Monica Pearl 1 , Gokhuldass Mohandas 1 , Amnon Bar-Shir 1 , Monika Barczewska 4 , Joanna Wojtkiewicz 4 , Aleksandra Habich 4 , Wojciech Maksymowicz 4 , Jeff W.M. Bulte 1 , Dara Kraitchman 1 , and Piotr Walczak 1,5
1
The Russell H. Morgan Department of
Radiology and Radiological Science, Johns Hopkins
University, Baltimore, Maryland, United States,
2
NeuroRepair
Department, Mossakowski Medical Research Centre PAS,
Warsaw, Mazovia, Poland,
3
F.M.
Kirby Research Center, Kennedy Krieger Institute,
Baltimore, Maryland, United States,
4
Department
of Neurology and Neurosurgery, University of Warmia and
Mazury, Olsztyn, Varmia and Masuria, Poland,
5
Department
of Radiology, University of Warmia and Mazury, Varmia
and Masuria, Poland
An intrathecal route was found to be a minimally
invasive and potentially efficient method of stem cell
delivery to the spinal cord. However, that approach is
highly challenging due to uncertain cell distribution.
Cell tracking with proton imaging proved difficult due
to omnipresent magnetic field inhomogeneity. We have
shown that suspending stem cells in a hydrogel improves
the targeted injection. Labeling of the hydrogel with
fluorine nanoparticles enables detailed and quantitative
depiction of stem cell distribution. The use of fluorine
image-guidance enables a very precise deployment of stem
cells within the intrathecal space.
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