Abstract #0633
Quantification of the Cerebral Microvasculature using High-Resolution BOLD-Based Vessel Size Imaging at 3 Tesla
Andreas Deistung 1 , Martin Krmer 1 , Ferdinand Schweser 1 , and Jrgen Rainer Reichenbach 1
1
Medical Physics Group, Institute of
Diagnostic and Interventional Radiology I, Jena
University Hospital - Friedrich Schiller University
Jena, Jena, Germany
We present a non-invasive approach for characterizing
the vasculature in the capillary regime with an
effective in-plane resolution of 2mm at 3 Tesla by
employing gradient echo sampling of FID and spin echo
(GESFIDE) with periodically rotated overlapping parallel
lines with enhanced reconstruction echo planar imaging
(PROPELLER-EPI). The analysis of the blood oxygenation
level dependency related signal changes provoked by
inhaling different gas mixtures (air, carbogen) resulted
in quantitative maps of vessel radius, deoxygenated
blood volume, and venous vessel density that enable
discrimination of anatomic structures. Furthermore,
average values across 23 equally-aged subjects are
presented for different tissue types.
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