Abstract #0578
Laminar-resolution BOLD and CBV fMRI responding to layer-specific neural modulations in the olfactory bulb
Alexander Poplawsky 1 , Mitsuhiro Fukuda 1 , Xiaopeng Zong 2 , and Seong-Gi Kim 1,3
1
Radiology, University of Pittsburgh,
Pittsburgh, PA, United States,
2
Biomedical
Research Imaging Center, University of North Carolina,
Chapel Hill, NC, United States,
3
Biological
Sciences, Center for Neuroscience Imaging Research,
Institute for Basic Science (IBS), SKKU, Suwon, Korea
We used high-resolution fMRI in the olfactory bulb model
to examine whether hemodynamic responses are regulated
at the laminar level. Odor and micro-stimulation of the
lateral olfactory tract (LOT) were used to
preferentially evoke activity in different bulb layers.
We found different, neural-specific laminar activation
patterns for each individual stimulation using CBV fMRI,
but not BOLD. Specifically, for CBV, a ring-like
activation was reproducibly observed only in middle
layers (~200 m thick) following LOT stimulation that
corresponds with the location of evoked neural activity.
Our data provide definitive evidence that the
hemodynamic response is regulated at the laminar level.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
