Abstract #0556
Measuring human glomerular morphology and pathology with MRI
Scott C. Beeman 1 , Luise Cullen-McEwan 2 , Min Zhang 3 , Teresa Wu 3 , Edwin J. Baldelomar 4 , John P. Dowling 2 , Jennifer R. Charlton 5 , Michael S. Forbes 5 , Amanda Ng 2 , Qi-zhu Wu 2 , James A. Armitage 2 , Victor G. Puelles 2 , Gary F. Egan 2 , John F. Bertram 2 , and Kevin M. Bennett 4
1
Washington University in St Louis, St Louis,
Missouri, United States,
2
Monash
University, Victoria, Australia,
3
Arizona
State University, Arizona, United States,
4
University
of Hawaii at Manoa, Hawaii, United States,
5
University
of Virginia, Virginia, United States
Nephron number and size are correlated with risk for
chronic cardiovascular and kidney disease and may
predict renal allograft viability. Unfortunately, there
are no techniques to assess total glomerular number and
volume in intact human kidneys. This work demonstrates
the use of cationized ferritin as a glomerulus-specific
MRI contrast agent to measure glomerular number, volume,
and spatial distribution and to detect arterial and
glomerular damage in human kidneys.
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