Abstract #0553
Diffusion-weighted MRI of advanced ovarian cancer: evaluation of the variability of overall disease burden assessment methods
Jennifer C Wakefield 1,2 , Stavroula Kyriazi 1 , Jessica M Winfield 1 , Veronica A Morgan 2 , Sharon L Giles 2 , David J Collins 1,2 , and Nandita M deSouza 1,2
1
Division of Radiotherapy and Imaging, The
Institute of Cancer Research, Sutton, Surrey, United
Kingdom,
2
Royal
Marsden NHS Foundation Trust, Sutton, Surrey, United
Kingdom
Variability of tumor volumetry and ADC in ovarian cancer
metastases was assessed in order to establish their
value as response biomarkers. Three tumor burden
assessment methods were employed (semi-automated region
growing and manual segmentation of DW-MRI data and
RECIST measurements on CT) and tumor volume and median
ADC determined in 16 patients with primary ovarian
cancer by a single radiologist. A second radiologist
assessed the tumor burden using an identical
semi-automated region growing method. Intra- and
inter-observer variabilities were evaluated by
calculating the Coefficient of Variation (CV). Volume
variability was: intra-observer CV 12.3%, inter-observer
CV 17.4%, median ADC variability was lower:
intra-observer CV 4.3%, inter-observer CV 4.2%.
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