Abstract #0535
In vivo 13 C MRS in the mouse brain at 14.1 T and metabolic flux quantification during infusion of [1,6- 13 C 2 ] Glucose
Marta Lai 1 , Bernard Lanz 1,2 , Carola Jaquelina del Carmen Romero 1,3 , Cristina Cudalbu 3 , and Rolf Gruetter 1,4
1
Laboratory of Functional and Metabolic
Imaging (LIFMET), Ecole Polytechnique Fdrale de
Lausanne, Lausanne, Switzerland,
2
Department
of Radiology, University of Lausanne, Lausanne,
Switzerland,
3
Centre
dImagerie Biomedicale, Ecole Polytechnique Fdrale de
Lausanne, Lausanne, Switzerland,
4
Departments
of Radiology, University of Lausanne and Geneva,
Switzerland
13
C MRS in conjunction with [1,6-
13
C]
Glucose infusion is a powerful tool to access in vivo
brain energy metabolism and neurotransmission.
Unfortunately, due to the intrinsic low sensitivity of
13
C
detection, acquisitions are commonly limited to fairly
big volumes restricting its in vivo application in the
rat brain. With our present work we want to overcome
these limitations proving the feasibility of
13
C
MRS in the mouse brain at 14.1 Tesla. Successful
completion of 10-minutes spectra acquisition in the
mouse brain allows metabolic fluxes quantification and
opens the possibility to study a wide range of
transgenic mice models in vivo.
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