Abstract #0512
Quantitative Vessel-Encoded Arterial Spin Labeling Reveals Collateral Blood Flow in Hyper-Acute Stroke Patients
Thomas W Okell 1 , George WJ Harston 2 , Michael A Chappell 3 , Fintan Sheerin 4 , Martino Cellerini 4 , Stephen J Payne 3 , James Kennedy 5 , and Peter Jezzard 1
1
FMRIB Centre, Nuffield Department of
Clinical Neurosciences, University of Oxford, Oxford,
Oxfordshire, United Kingdom,
2
Nuffield
Department of Medicine, University of Oxford, Oxford,
Oxfordshire, United Kingdom,
3
IBME,
Department of Engineering Sciences, University of
Oxford, Oxford, Oxfordshire, United Kingdom,
4
Department
of Neuroradiology, Oxford University Hospitals NHS
Trust, Oxford, Oxfordshire, United Kingdom,
5
Radcliffe
Department of Medicine, University of Oxford, Oxford,
Oxfordshire, United Kingdom
Multi-postlabeling delay vessel-encoded arterial spin
labeling is capable of generating artery specific
quantitative maps of cerebral blood flow and bolus
arrival time non-invasively and without contrast agent.
This method was applied to serially study hyper-acute
stroke patients. Changes in the vascular territories
over time were observed, with collateral flow appearing
to spare tissue from infarction. Significant delays to
blood arrival were measured in regions around the
perfusion deficit compared to the contralateral side.
This technique shows promise for diagnosis, prognosis
and understanding the pathophysiology of acute stroke.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
