Abstract #0485
In vivo measurements of acute pain induced changes of GABA+ and Glx in the brain by using functional 1 H-MEGA-PRESS MR spectroscopy
Marianne Cleve 1 , Alexander Gussew 1 , and Jrgen R. Reichenbach 1
1
Medical Physics Group, Institute of
Diagnostic and Interventional Radiology I, Jena
University Hospital - Friedrich Schiller University
Jena, Jena, Germany
: This study comprises results of time resolved
measurements of acute heat pain induced changes in
excitatory (Glx) and inhibitory (GABA+) neurotransmitter
turnover in the aCC by using 1H-MEGA-PRESS spectroscopy.
Compared to the reference condition Glx/tCr increased
significantly up to a median value of 14.2% in aCC
during stimulation. At the same time, GABA+/tCr
decreased by a median value of 25.4%. The Glx/tCr
increase may be ascribed to the elevated glutamatergic
turnover, while the GABA+/tCr decrease may reflect
reduced activity of the inhibitory system during pain
processing.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
