Abstract #0462
Assessing Activation Induced Changes in Creatine Kinase Activity in the Human Brain using 31P Spectroscopy with Magnetisation Transfer
Chen Chen 1 , Penny Gowland 1 , Susan Francis 1 , Mary Stephenson 1 , Peter Morris 1 , and Andrew Peters 1
1
Sir Peter Mansfield Magnetic Resonance
Centre, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom
31P magnetic spectroscopy with magnetisation transfer
was used to investigate changes in creatine kinase (CK)
kinetics induced in human visual cortex during visual
stimulation by measuring the unidirectional PCr->ATP
rate constant (k1). Results revealed that 1) intrinsic
and apparent spin-lattice relaxation time T1 of PCr at
3T are 4.670.91s and 1.510.18s, respectively; 2) k1
increased by 17 12 % during visual stimulation,
indicating that CK turnover is elevated during increased
neuronal activity.
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