Abstract #0421
White Matter Perfusion Measurement using Velocity-Selective Arterial Spin Labeling A Comparison with Pulsed ASL and Pseudo-Continuous ASL
Jia Guo 1 and Eric C. Wong 2
1
Department of Bioengineering, University of
California San Diego, La Jolla, California, United
States,
2
Departments
of Radiology and Psychiatry, University of California
San Diego, La Jolla, California, United States
It is challenging to measure WM CBF using ASL due to the
low WM CBF and the heterogeneous and long transit
delays. VSASL is inherently insensitive to transit
delays, but for typical parameters it has a lower SNR
than conventional ASL methods such as PCASL. However,
compared with PCASL in which a long PLD was required in
WM measurements, VSASL with two Velocity Selective
Saturation (VSS) modules provided a comparable SNR
(P=0.52) and CBF values (P=0.61) in WM, and even had a
higher SNR in GM (P<0.01). VSASL may be more favorable
than other tagging methods in applications where long
transit delays are expected.
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