Abstract #0356
Effect of chronic administration of -hydroxybutyrate in spontaneously epileptic kcna1-null mice measured with Manganese Enhanced MRI (MEMRI)
Gregory Harrison Turner 1 , Johana Vallejo 2 , Mohammed Abdelwahab 3 , Qingwei Liu 1 , Lana Leung 2 , Younghee Ahn 4 , Jong Rho 4 , and Do Young Kim 3
1
Neuroimaging Research, Barrow Neurological
Institute, Phoenix, AZ, United States,
2
Physiology,
Midwestern University, Glendale, AZ, United States,
3
Barrow
Neurological Institute, AZ, United States,
4
Alberta
Children's Hospital, University of Calgary, Alberta,
Canada
Chronic in vivo administration of BHB results in a
significant anticonvulsant effect in Kcna1-null mice.
Moreover, Manganese Enhanced MRI found that BHB alone
appears to exert a structural neuroprotective effect in
hippocampus. The combination of morphological and
functional neuroprotective effects of BHB in this
genetic model of epilepsy suggests that KB may be
beneficial for neurological conditions other than
epilepsy.
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